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5th World Congress on Cancer Therapy

Atlanta, USA

Paul Bremond

Aix-Marseille University, France

Title: Alkoxyamines for the in-situ generation of radicals as theranostic agents


Biography: Paul Bremond


Alkoxyamines R1R2NOR3 are able to undergo homolysis upon chemical activation to release a stable nitroxide R1R2NO•, which can be used for DNP-MRI, and a transient alkyl radical R3•, which can be used for killing tumor cells. By combining diagnostic and therapeutic activities into a single low-molecular weight molecule, alkoxyamines are new theranostic tools. We have developed this concept recently, and proved that they are reliable and controllable sources of in-situ generated radicals able to exhibit interesting biological and imaging properties.