5th World Congress on Cancer Therapy
Emory University School of Medicine, USA
Title: Bioengineered Fusokine GIFT4 for cancer immunotherapy
Biography: Jiusheng Deng
Emerging evidences show immunotherapy by enhancing our own immune system has become an attractive approach for cancer treatment due to the rapid drug resistance of chemotherapy. Fusion cytokines derived from GM-CSF and common γ-chain interleukins have potent gain-of-function properties to alter host immune response. Recently, we have generated a newly bioengineered fusokine GIFT4 that is derived from GM-CSF and IL-4, and tested the bioactivity of GIFT4 as a potential immunotherapeutic agent against caner. We observed that GIFT4 directly elicits anti-tumor adaptive B-cell immune response and consequent T cell immunity in vitro and in vivo. Murine GIFT4 expression suppresses melanoma tumor growth in immunologically intact mouse and administration of GIFT4 protein inhibits murine melanoma growth in vivo. GIFT4-B cell primed cytotoxic T cells from melanoma patients specifi cally kill human melanoma cells in vitro and in immune defi cient NSG mice. Th us, GIFT4 defines a novel engineered cytokine that mediates endogenous expansion of B-cells with potent anti-tumor eff ector function. We propose that GIFT4 protein could serve as a novel immunotherapeutic agent and defines a previously unrecognized potential of B-cells for personalized cancer cell immunotherapy. We expect that GIFT4 as an anti-melanoma agent will provide a novel strategy and opens a new avenue for human B cell-based immunotherapy against melanoma. We propose that GIFT4-B cells could serve as a potent immunotherapeutic agent and defi ne a previously unrecognized potential of B-cells for personalized cancer cell immunotherapy.