5th World Congress on Cancer Therapy
Larkin Health Sciences Institute College of Pharmacy, USA
Title: Chemoprevention of experimental mammary carcinoma by Trianthema portulacastrum Linn., an Indian dietary and medicinal plant
Biography: Anupam Bishayee
Breast cancer is the most frequently diagnosed cancer and the primary cause of cancer-related death in women worldwide. Since\r\nthere are limited treatment options for advanced-stage metastatic breast cancer, a high priority should be given to develop\r\nsafe chemopreventive drugs. Th e value of various natural and dietary agents to reduce the risk of breast cancer development is\r\nwell established. Trianthema portulacastrum Linn. (Aizoaceae), an Indian dietary and medicinal plant, has been found to exhibit\r\nantihepatotoxic and antihepatocarcinogenic activities in rodents. Th e current study was initiated to investigate mechanism-based\r\nchemopreventive potential of a well characterized ethanolic extract of T. portulacastrum (TPE) against 7, 12-dimethylbenz(a)\r\nanthracene (DMBA)-induced rat mammary carcinogenesis, an experimental breast tumor model that closely mimics human\r\ndisease. Rats had free access to a basal diet supplemented with TPE to yield three dietary doses (i.e., 50, 100 and 200 mg/kg\r\nbody weight) throughout the experimental period (18 weeks). Following 2 weeks of TPE treatment, mammary tumorigenesis was\r\ninitiated by oral administration of DMBA (50 mg/kg body weight). At the end of the study (16 weeks aft er DMBA exposure), TPE\r\nhas been shown to exert a drastic reduction of DMBA-induced mammary tumor incidence, total tumor burden and average tumor\r\nweight as well as reversed intratumor histopathological alterations. TPE dose-dependently reduced the expression of proliferating\r\ncell nuclear antigen and cyclin D1, induced apoptosis, upregulated proapoptotic protein Bax, downregulated antiapoptotic protein\r\nBcl-2, diminished Wnt/-catenin signaling and suppressed nuclear factor-kappaB-mediated infl ammatory cascade in mammary\r\ntumors. Our results clearly provide the fi rst experimental evidence that TPE aff ords chemopreventive eff ect in the classical DMBA\r\nmodel of breast cancer by impeding multiple oncogenic pathways during an early-stage breast cancer. Th ese results may encourage\r\nfurther studies to develop T. portulacastrum phytoconstituents as breast cancer chemopreventive drugs.