5th World Congress on Cancer Therapy
Genomics Research Center, Academia Sinica, Taiwan
Title: Combining ultrasound and nanoparticle for cancer treatment
Biography: Chung-Hsuan (Winston) Chen
We will present the concept and data for a cancer-specifi c treatment that combines ultrasound and nanoparticles to induce cytotoxicity in cancer cells relative to normal cells. Co-cultures of BEAS-2B normal lung cells and A549 cancerous lung cells labeled with green- and red-fl uorescent proteins respectively, were treated with focused ultrasound beams with the addition of gold and magnetic nanoparticles. Th ere were signifi cantly more necrotic A549 cells than BEAS-2 cells when gold nanoparticles were added to the culture medium. Th is selective damage to cancer cells was also observed for MDAMB231 breast cancer cells compared with MCF-10A normal breast cells aft er treatment with magnetic nanoparticles. Th e data obtained for diff erent cell lines indicate that nanoparticle-assisted ultrasound therapy could be an eff ective new tool for cancerspecific treatment and could potentially be combined with conventional methods of cancer diagnosis and therapy to further increase the overall cancer cure rate.