5th World Congress on Cancer Therapy
Damanhour University, Egypt
Title: Design, synthesis and antiproliferative activity of 6-substituted Pyridazin- 3(2H)-ones
Biography: Mohamed Elagawany
Cancer is not just one disease, but a generic term used to encompass a group of more than two hundred diseases sharing common characteristics. Among all diseases that aff ect humanity, cancer ranks high as a major killer. Although major advances have been made in the chemotherapeutic management of some patients, the continued commitment to the arduous task of discovering new anticancer agents remains critically important. Th e discovery that several novel series of 3(2H)- pyridazinones possess characteristic pharmacological and biological activities stimulated great interest in pyridazine chemistry, which continues to this day. In this work the design and synthesis of 6-substituted pyridazinone derivatives are described. Antiproliferative screening revealed that novel compounds have modest activity against MCF-7 “breast cancer cell line”. SAR analysis and docking calculations were carried out to aid in the interpretation of the results. Taken together, our fi ndings suggest that 6-substituted pyridazinone scaff olds are interesting starting points for design of novel potent anticancer drugs.