5th World Congress on Cancer Therapy
Kurukshetra University, India
Title: Implications for antimicrobial, anticancer activity and molecular docking studies of N4- Tetradentate Tin macrocycles
Biography: Ekta Rawat
Despite many efforts, cancer is among the top three causes of death in modern society, demanding improved treatments, that currently includes surgery, chemotherapy, and various types of radiation therapy. Inorganic medicinal chemistry has been dominated by the study of the anti-cancer properties of macrocyclic metal complexes. Th ere are a compelling number of drug targets where macrocycles have the potential to bind with good affinity. Metallomacrocycles is an outstanding tool for making structurally matching complexes with drastically diff erent anticancer potentials. Macroyclic complexes possess a number of advantages that render them as attractive alternatives to organic small molecules for the development of therapeutic agents. In this perspective, we highlight recent advances in medicinal inorganic chemistry pertaining to the use of macrocyclic ligands for enhanced antimicrobial and anticancer activity. A novel series of macrocyclic complexes of Tin(II) have been derived from dicarboxilic acids and diamines. Characterizations were accomplished through elemental analyses, molecular weight determinations, infrared and multinuclear NMR studies to investigate their respective molecular structures. The spectral and computational studies are in good agreement with proposed framework of new complexes and supported an octahedral geometry around tin. Th e system described has been explored theoretically using molecular docking simulations. Th e complexes were screened against pathogenic fungi and bacterial strains. Some very active compounds were tested for anticancer activity against a panel of cell lines. Th e newly synthesized compounds displayed appreciable inhibitory potency in comparison with the standards.