5th World Congress on Cancer Therapy
Nanjing First Hospital, China
Title: Polymorphisms in one- carbon metabolism pathway affect survival of Chinese resected gastric cancer patients
Biography: Jinfei Chen
Defi ciencies in one-carbon metabolism (OCM) infl uence risk for human cancers. Th e associations and contributions of single nucleotide polymorphisms (SNPs) of genes in OCM pathway are unclear. We investigated the eff ects of SNPs of genes in OCM pathway on the survival of gastric cancer (GC) patients, including Methylenetetrahydrofolate reductase (MTHFR) (677C>T, 1298A>C), Methionine synthase reductase (MTRR) (66A>G), Methionine synthase (MTR) (2756A>G), and Th ymidylate synthase (TYMS/TS) (3’-UTR ins6 > del6, 5’-UTR 2R>3R). We recruited 919 GC patients from 1998 to 2006. Th e Kaplan–Meier plots, Cox regression analyses and the log-rank tests were carried out in this study. MTHFR 1298CC genotype showed protective eff ect (HR = 0.444, 95% CI = 0.210–0.940). MTRR 66 GA + GG genotypes decreased the risk of death (HR = 0.793, 95% CI = 0.651–0.967) in general, and in subgroups with more pronounced among Diff use type, more depth of invasion (T2/T3/T4), higher level lymph node metastasis (N1/N2/N3), advanced TNM stages (II/III level) and 5-Fu treatment. However, the improved survival disappeared when GC patients simultaneously had MTR 2756 GA + GG genotypes (HR = 1.063, 95% CI = 0.750–1.507). Although MTRR 66GA genotype was not associated with the survival of GC patients, patients with simultaneous MTRR 66GA and MTR 2756AA genotypes exhibited signifi cant risk reduction of death (HR = 0.773, 95% CI = 0.609–0.981). MTHFR 1298 CA + CC combined with TYMS 5-UTR 2R3R + 3R3R genotypes (HR = 0.536, 95% CI = 0.315– 0.913) also increased patient survival rates. Our results suggest that the MTRR 66A>G and MTHFR 1298A>C polymorphisms may be useful prognostic molecular biomarkers for GC patients.