5th World Congress on Cancer Therapy
The Second Hospital of Shandong University, China
Title: Profiling cancer gene mutations in non-small cell lung cancer by droplet digital PCR
Biography: Dongqi Tang
As a noninvasive liquid biopsy, plasma cell-free DNA (cfDNA) was studied as a potentially valuable surrogate specimen for detecting tumor-specifi c aberrations. Non-small cell lung cancer (NSCLC) is the common type of lung cancer, which is the leading cause of cancer death throughout the world. Most patients were diagnosed too late for curative treatment. So, it is necessary to develop a minimal invasive method to identify NSCLC at an early stage. Here, we studied cfDNA collected from subjects with advanced NSCLC by performing droplet digital PCR on serial cfDNA specimens collected from patients and healthy control. Our fi ndings demonstrated that the ctDNA could serve as a viable tool to monitor NSCLC and prompted us to find more sensitive and specifi c biomarkers for clinical practice, especially monitor these cases with at least one known gene abnormality.