5th World Congress on Cancer Therapy
Sinhgad Institute of Pharmaceutical Sciences, India
Title: Resveratrol gold nanoparticles: Synthesis, characterization and in-vitro anticancer activity
Biography: Shrinivas Bumrela
The biosynthesis of nanoparticles has been proposed as a cost eff ective and environmental friendly alternative to chemical and physical methods. Gold nanoparticles were synthesised using standardized resveratrol extract as reducing agents. Th e method described a novel application of resveratrol and fortifi es the screening of a new potential source of reducing agent for the synthesis of Au-R-NPs. Th e particle size of Au-R-NP was found in the range from 50-100nm and is in the reported size range of NP. Th e zeta potential of Au-R-NP was found to be -22.64 mV, validated the size and the charge of the nanoparticles in colloidal solution without any aggregation. Pure drug has characteristic exothermic melting peak at 132.34°c with high intensity. FTIR studies confi rmed the biofabrication of the Au-R-NPs by the action of its diff erent functional groups present in the reducing agent. TEM analysis of AU-R-NPs revealed spherical shape and narrow size distribution. Au-R-NPs were screened for in-vitro anticancer activity on human lung carcinoma A-549 cell line. Au-R-NPs exhibited promising in-vitro anticancer activity with IC50 value of 10μg.