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5th World Congress on Cancer Therapy

Atlanta, USA

Deniz Peker

University of Alabama, USA

Title: Secondary malignancies as long term adverse effects of chemo- and radiation therapy

Biography

Biography: Deniz Peker

Abstract

This lecture will address variety of malignancies including acute leukemias, lymphomas and myelodysplastic syndromes that occur as a result of prior cytotoxic chemo- and/or radiation therapy. Secondary malignancies are highly aggressive diseases with less favorable outcome compared to their de novo counterparts. Th ese tumors oft en carry chromosomal abnormalities that are associated with refractory disease with short survival rates. Th erefore, the majority of these patients do not respond to conventional treatments that indicates the requirement for more targeted treatments. Th e speaker will explain pathophysiology of secondary malignancies with molecular and genetic features, treatment options and clinical course based on the professional experience and the literature. In additions to these subjects, the attendees of this lecture will be familiarized with the need for rigorous genetic analysis of these tumors to develop candidate targeted therapeutics, so that these patients may be off ered more eff ective and less toxic treatment options.