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25th World Congress on Cancer Science and Therapy

Baltimore, USA

Wassil Nowicky

Ukrainian Anti-Cancer Institute, Austria

Title: Angiogenic properties of NSC-70 (UKRAIN/NSC-631570)

Biography

Biography: Wassil Nowicky

Abstract

Another important feature of NSC-631570 is the inhibition of the formation of the new blood vessels supplying a tumor. Due to these antiangiogenic properties NSC-631570 administered before surgery brings about better demarcation of the tumor from surrounding tissue and the tumor encapsulation. This alleviates the surgical removal of tumors what has been confirmed in breast cancer studies [67, 71, 103-106, 140]. In tests in vitro, NSC-631570 inhibited in a dose-dependent manner the proliferation of human endothelial cells without exerting cytotoxic effect. The angiogenesis inhibition was observed on the capillary formation model [134]. This inhibition of the neoangiogenesis prevents the metastasis formation as well.