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25th World Congress on Cancer Science and Therapy

Baltimore, USA

Mohammad Obaidul Hoque

Johns Hopkins University, USA

Title: Stem cell factors and markers: Biomarkers for bladder cancer detection and target therapy

Biography

Biography: Mohammad Obaidul Hoque

Abstract

Bladder cancer (BCa) is classified as non-muscle-invasive BC (NMIBC) or muscle-invasive BC (MIBC). Because the recurrence and mortality rates of BCa are high, suitable biomarkers for early detection and targeted therapy are needed. Cancer stem cells (CSCs) have been shown to contribute to tumorigenesis and therapeutic resistance. In a recent study we found that CSC factors can be detected in the urine of BCa patients with high sensitivity and specificity and targeting CSC pathways elicits a long-lasting therapeutic response by limiting CSC expansion following chemotherapy and EGFR inhibition in BCa.