Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer

Back

25th World Congress on Cancer Science and Therapy

Baltimore, USA


Hem D Shukla

University of Maryland, USA

Biography

Hem D Shukla is a Research Scientist in the Department of Pharmaceutical Sciences at University of Maryland and adjunct Professor of Genomics in Notre Dame of Maryland University. He has also worked as Research Faculty in Department of Biology at Johns Hopkins University. He has worked on proteomic analysis of oxidative stress response in BxPC-3 pancreatic cell lines and identification of biomarkers for early detection of pancreatic cancer. He has worked on “The Nrf2 mediated antioxidant defense against oxidative stress in pancreatic cancer cell lines and targets for therapeutic intervention”. He has shown elevated level of Nrf2 transcriptional factor in pancreatic cancer cell lines under oxidative stress, which is phosphorylated by protein kinase C and affects phosphatidylinositol 3-kinase and MAP kinase pathways. After phosphorylation, Nrf2 translocates to the nucleus, binds AREs and transactivates detoxifying enzymes and antioxidant enzymes, such as glutathione S-transferase and superoxide dismutase. The IPA analysis has suggested a potential role of Nrf2 under oxidative stress conditions. His research interests are: proteomic analysis of oxidative stress response in BxPC-3 pancreatic cell lines, identification of biomarkers for pancreatic cancer and Nrf2 mediated antioxidant defense against oxidative stress in pancreatic cancer cell lines.

Abstract

Abstract : Oxidative stress induced NRF2 regulation in BxPC-3 pancreatic cancer cells and identification of therapeutic targets