Dawn Lynn Guardiario
Philippine College of Physicians, Philippines
Title: Achievement of pathologic complete response of patients with locally advanced rectal adenocarcinoma: A 5-year single institution experience in Cebu, Philippines
Biography
Biography: Dawn Lynn Guardiario
Abstract
Introduction: Rectal Neuroendocrine Tumors (NETs) are hindgut carcinoid tumors that originated from the neuroendocrine system of the gastrointestinal tract. This report presents a case of an adult Filipino with recurrent episodes of hematochezia.
Case Presentation: A 33 year old Filipino presented with recurrent hematochezia. On the recent hospital admission, lower endoscopy was employed which revealed a small sessile rectal polyp. Endoscopic polypectomy was done. Histopathologic study revealed findings suggestive of a neuroendocrine tumor. Diagnosis was confirmed using immunohistochemistry study which was consistent with a neuroendocrine lesion with positive expression of synaptophysin antibody marker and weakly reactive chromogranin antibody marker.
Conclusion: Rectal NETs are benign tumor of the gastrointestinal tract. Most patients are asymptomatic and diagnosis is mainly done during endoscopic examination. Immunohistochemistry study is needed for confirmation of diagnosis. Treatment modalities are mainly based on the tumor grade and stage. Endoscopic resection is usually done for low grade tumors whereas surgical intervention such as anterior resection or abdominoperineal extirpation and medical therapy using Interferon-alfa and platinum based chemotherapy are recommended for high grade tumors.