5th Asia-Pacific Summit on Cancer Therapy
The University of Queensland, Australia
Title: An innovative platform for rapid and multiplexed cancer biomarker detection with surface-enhanced raman scattering nanotags
Biography: Yuling Wang
Surface enhanced Raman scattering (SERS) nanotags are a new class of labels for optical detection based on Raman scattering. Central advantages include the tremendous spectral multiplexing capacity for simultaneous target detection due to the narrow width of vibrational Raman bands, the need for only a single laser excitation wavelength to excite the Raman spectra of all SERS nanotags, quantification using the fingerprint intensity of the corresponding SERS nanotags; high photostability and optimal contrast by using red to near-infrared (NIR) excitation in order to minimize the disturbing auto fluorescence of cells and tissues. In this contribution, the innovative platform for rapid and multiple cancer biomarker detection such as epigenetic biomarker (DNA methylation) and protein biomarker (HER2) by using rational designed SERS nanotags will be discussed.