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13th Asia-Pacific Oncologists Annual Meeting

Kualalumpur, Malaysia

Devishree V Rai

Devishree V Rai

SDM College of Dental Sciences and Hospital, India

Title: Association of VEGF gene as prognostic marker in subjects with oral submucous fibrosis (OSMF) of North Karnataka population

Biography

Biography: Devishree V Rai

Abstract

Oral cancer imposes a considerable problem worldwide being a highly lethal and disfiguring disease. According to the report of the World Health Organization, oral cancer is the sixth most common cancer worldwide and the most common intraoral subtype is squamous cell carcinoma. The formation or progression of oral cancer may be associated with a polymorphism of the vascular endothelial growth factor (VEGF) gene. OSCC was associated with significantly elevated serum VEGF concentration and higher level of serum VEGF also correlated with lymph node metastasis and clinical stage of OSCC. There have been association of VEGF-460C/T polymorphism in oral cancer, diabetic retinopathy, breast cancer, prostate cancer, but very few studies are known to validate the association of the VEGF gene with potentially premalignant conditions like oral submucous fibrosis. The most frequently seen polymorphism is BstUI (C to T) located at the -460th nucleotide upstream of the VEGF gene. With the malignant transformation rate of OSMF being 7-30%, VEGF gene -460C/T can become an important prognostic marker. The aim of our study was to assess the polymorphic nature of VEGF -460C/T gene in subjects with oral submucous fibrosis of North Karnataka population and analyze the comparison between the association of VEGF -460C/T polymorphism in patients with oral submucous fibrosis and healthy controls.