Wassil Nowicky
Ukrainian Anti-Cancer Institute, Austria
Title: The angiogenic properties of NSC-631570
Biography
Biography: Wassil Nowicky
Abstract
Another important feature of medical preparation NSC-631570 after its selective effect (in therapeutic dosage it kills only cancer cells leaving the healthy cells undamaged) is the inhibition of the formation of the new blood vessels supplying a tumor. Due to these anti-angiogenic properties NSC-631570 administered before surgery brings about better demarcation of the tumor from surrounding tissue and the tumor encapsulation. This alleviates the surgical removal of tumors what has been confirmed in breast cancer studies. In in vitro tests; NSC-631570 inhibited in a dose dependent manner, the proliferation of human endothelial cells without exerting cytotoxic effect. The angiogenesis inhibition was observed on the capillary formation model. This inhibition of the neoangeogenesis prevents the metastasis formation as well.