Esam Omar
Taibah University, Saudi Arabia
Title: Current concepts and future of salivary markers for diagnosing oral squamous cell carcinoma: A review and analysis of relevant published studies
Biography
Biography: Esam Omar
Abstract
Background: Oral squamous cell carcinoma (OSCC) has a remarkably high incidence worldwide, and a fairly serious prognosis, encouraging further research into advanced technologies for noninvasive methods of making early diagnoses, ideally in primary care settings. Objective: Our purpose was to examine the validity of using salivary markers changes in OSCC,s patients by advanced nanotechnology and molecular diagnostics for diagnosing OSCC by identifying and evaluating relevant published reports. Methods: MEDLINE, EMBASE, and CINAHL were searched to identify clinical trials and other information published between 1990 and 10 June 2014; the searches of MEDLINE and EMBASE were updated to November 2014. Studies of noninvasive methods of diagnosing OSCC (saliva-based diagnosis and others were included). Data were abstracted and evaluated in duplicate for possible relevance on two occasions at an interval of 2 months before being included or excluded. Studies met the inclusion criteria and have been assessed by modifi ed version of the Quality Assessment of Diagnostic Accuracy Studies instrument. Findings: 42 studies of saliva based oral diagnosis met the inclusion criteria. Salivary diagnostics is a dynamic and emerging fi eld utilizing nanotechnology and molecular diagnostics that can be helpful in diagnosis of OSCC. Conclusions: It is clear that screening for and early detection of cancer and pre-cancerous lesions have the potential to reduce the morbidity and mortality of this disease. Advances in nanotechnology for saliva-based oral diagnosis are a promising pathway for the future development of more eff ective noninvasive methods for diagnosing OSCC that are easy to perform clinically in primary care settings. Key words: Oral cancer, noninvasive methods, saliva based diagnostics