Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer

Back

12th World Cancer Conference

London, UK

Qingyong Ma

Qingyong Ma

First Affiliated Hospital, Xi'an Jiaotong University, China

Title: Desmoplasia Suppression by Metformin-mediated AMPK Activation Inhibits Pancreatic Cancer Progression

Biography

Biography: Qingyong Ma

Abstract

The desmoplastic reaction is one of the most prominent histological features of pancreatic ductal adenocarcinoma (PDAC), and it contributes to the aggressive nature of PDAC cells. Persistent activation of pancreatic stellate cells (PSCs) induced by cancer cells is responsible for the desmoplastic reaction in PDAC. AMP-activated protein kinase (AMPK) is a highly conserved serine/threonine protein kinase that is involved in regulating pathological fibrosis processes. Recently, emerging evidence has suggested that metformin may be useful in preventing and treating cancer; however, the underlying mechanism remains relatively unknown. In this study, using histological analysis, we found that low P-AMPK staining correlated with a dense stroma reaction and a poorer prognosis in PDAC. Furthermore, metformin-induced AMPK activation in cancer cells inhibited the desmoplastic reaction and prevented tumor growth in mice with subcutaneous pancreatic cancerIn vitro experiments demonstrated that metformin inhibited pancreatic cancer cell migration and invasion; more interestingly, metformin suppressed PSC activation during direct and indirect PC-PSC co-culture conditions by inducing AMPK phosphorylation only in PCs and downregulating fibrogenic-related cytokine  production in PCs. More importantly, the combination of metformin with gemcitabine enhanced the antitumor effect of gemcitabine without affecting the blood glucose levels of mice. In conclusion, our findings uncover the mechanism underlying the antitumor effect of metformin. Additionally, inducing AMPK activation in PCs can reduce the desmoplastic reaction by targeting the interaction between PSCs and PDAC cells and may represent a novel therapeutic approach for treating advanced PDAC.