Angel Danchev Yordanov
UMHAT “Doctor Georgi Stranskiâ€-Pleven, Bulgaria
Title: Lymhoepithelioma-like carcinoma of the uterine cervix¬ – association with Epstein-Barr Virus and Human Papillomavirus
Biography
Biography: Angel Danchev Yordanov
Abstract
Introduction: Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rare variant of squamous cell carcinoma (SSC). It differs from the usual SSC of the cervix in its morphology and clinical behavior and shows a better prognosis than the more common SSC of the cervix. It is associated with EBV infection in Asian women and with HPV or no infection in Caucasian patients.
Aim: Our aim is to confirm whether or not LELC is more common in Caucasian patients with EBV/HPV infection or whether there is no correlation to the previous viral exposure. We try to link the viral status with the survival rate and the prognosis.
Materials and methods: A retrospective research has been done on 775 female patients for a period of 8 years, who have been operated for cervical cancer in the Oncogynecological Department of UMHAT “Doctor Georgi Stranski”-Pleven. A group of 16 women with LELC have been identified by clinical data. Morphologically the patients have been examined routine-histologically and immunohistochemically, for assessment of the viral status, with monoclonal antibodies against EBV/HPV by DAKO protocol.
Results: Three of the women have been proven to have EBV and one-HPV infection. In the other cases no viral infection have been identified.
Conclusion:Our results show a stronger correlation between LELC in Caucasian women and a previous EBV infection or no viral infection, rather than association with HPV infection. This data is very different from the previous research, that has been done on this topic.