12th World Cancer Conference
University of Science & Technology of China, China
Title: p53 protects tumor cell survival via a long non-coding RNA under glucose starvation
Biography: Mian Wu
p53 is one of the most important tumor suppressors that have been found thus far. Approximately 50% of tumors harbour p53 mutations and which is belived to contribute to tumor's maliganicy. However, the remaining 50% of tumors possess wild type p53, and the exact role it plays in tumor cells is not clear. Cancer cells prefer to metabolize glucose through aerobic glycolysis, known as the Warburg effect. Due to its low efficiency of ATP production, it is therefore resonable to believe that tumor cell rely more heavily on glucose compared to normal cells. Yet under glucose starvation conditions, we found wild type p53 can upregulates a long noncoding RNA, which interferes with a novel necrotic signaling pathway, and protects tumor cells aganist necrosis under glucose starvation. Our data suggest that wt-p53 can acs as an oncogenic factor to promote tumor cell survival by metabolic reprograming.