Dhabadge Vivek Nanasaheb
Swami Ramanand Teerth Marathwada University, India
Title: Effect of methanolic extract of Ailanthus excels (Bark) Roxb. on human breast cancer cells
Biography
Biography: Dhabadge Vivek Nanasaheb
Abstract
Ailanthus excelsa Roxb is deciduous tree from the family Simaroubaceae and widely distributed in Asia and china A.excelsa is used to cure wounds and skin eruption and is used in the indigenous system of medicine febrifuge, bronchitis, asthama, and in condition of diarrhea and dysentery. A excelsa extract and some isolated compound have demonstrated medicinal properties such as significant antileukemic, antibacterial, antifungal and antifertility activites. The present work was desigined to evoulate in vitro anticancer activity of bark of A. excelsa against human breast cancer cells. Methanolic extract of bark of A. excelsa was evaluated for inhibition of cell proliferation and migration of human breast cancer cell line MDA-MB-231. MTT- based cytotoxicity assay was used to assess the effect of methanolic extract of bark of A. Excelsa against proliferation of human breast cancer cell line. Wound healing migration assay was used to assess the effects on the migration ability of human breast cancer cells. Methanolic extract of A. excelsa showed significant anticancer activity against MDA-MB-231 human breast cancer cell line.
