9th Indo Global Summit on Cancer Therapy
Chaitanya Degree and Postgraduate College, India
Title: Isolation and estimation of phytic acid in microbes
Biography: S Suma
Phytic acid, myo-inositol [1, 2, 3, 4, 5, 6 hexakis phosphate] (IP6) is a common chemical component present in cereals and seeds. Phytic acid or its salt (phytate) is the principal storage form of phosphorus (P) and inositol. Phytic acid (IP6) is naturally available in plant based foods such as legumes, wheat bran and soya foods. The physiological role of IP6 in animals and its role as anti-cancer agent have been widely studied. Unlike most other anticancer agents, IP6 blocks the cell cycle of the malignant cells, forcing them to revert to a non-cancerous state. Further, IP6 controls the cell division and reduces the rate of cellular proliferation both in vivo and in vitro. Phytase enzyme in microbes converts the phytic acid into phosphates (P) and simple inositol. The major problem with phytase enzyme is lack of information regarding the activate site, biophysical properties which can be altered without sacrificing the enzyme stability and activity. We have presented biochemical and biophysical parameters of different phytases as this information was limited in previous reviews.