9th Indo Global Summit on Cancer Therapy
Indian Institute of Technology -Roorkee, India
Title: Synthesis and in-vitro studies of novel 5-fluorouracil pro-drugs using xylan as a carrier for sustained release
In order to develop a sustained release drug delivery system for colon specific drug delivery, a novel Xylan-based 5-fluorouracil pro-drug was synthesized in two step method. Firstly, Xylan is extracted from corn-cob as an agro waste. Secondly, 5-fluorouracil-1-acetic acid (FUAC) was prepared and then covalently conjugated to Xylan through ester linkage. Prepared conjugates were characterized by analytical techniques such as FTIR and NMR. The successful synthesis was further confirmed by DSC/TGA and powder X-ray diffraction techniques. The degree of substitution was estimated by complete hydrolysis of conjugates in alkaline solution. In-vitro hydrolysis study of conjugates was performed in acidic (pH 1.2) and basic (pH 7.4) buffers, showed their stability in upper GIT environment, which is the primary requirement of colon specific drug delivery. The synthesized Xylan based ester prodrug of 5-fluorouracil is found to be the potential candidate for colon targeted drug delivery with minimal undesirable side effects.