Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer

Back

9th Indo Global Summit on Cancer Therapy

Hyderabad, India

Sauraj

Sauraj

Indian Institute of Technology -Roorkee, India

Title: Synthesis and in-vitro studies of novel 5-fluorouracil pro-drugs using xylan as a carrier for sustained release

Biography

Biography: Sauraj

Abstract

In order to develop a sustained release drug delivery system for colon specific drug delivery, a novel Xylan-based 5-fluorouracil pro-drug was synthesized in two step method. Firstly, Xylan is extracted from corn-cob as an agro waste. Secondly, 5-fluorouracil-1-acetic acid (FUAC) was prepared and then covalently conjugated to Xylan through ester linkage. Prepared conjugates were characterized by analytical techniques such as FTIR and NMR. The successful synthesis was further confirmed by DSC/TGA and powder X-ray diffraction techniques. The degree of substitution was estimated by complete hydrolysis of conjugates in alkaline solution. In-vitro hydrolysis study of conjugates was performed in acidic (pH 1.2) and basic (pH 7.4) buffers, showed their stability in upper GIT environment, which is the primary requirement of colon specific drug delivery. The synthesized Xylan based ester prodrug of 5-fluorouracil is found to be the potential candidate for colon targeted drug delivery with minimal undesirable side effects.