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 Susanta Roychoudhury

Susanta Roychoudhury

Chief Scientist
CSIR-IICB
India

Biography

Genetic and epigenetic alterations of mismatch repair and spindle assembly checkpoint genes in oral cancer are being analysed to understand the molecular basis of genomic instability. The mechanism of spindle assembly checkpoint is being investigated to understand its role in aneuploidy. Systematic search for the single nucleotide polymorphisms in DNA repair genes is being carried out to identify the susceptibility alleles for the development of oral cancer. We are studying the association between cytokine and chemokine genes polymorphisms and Helicobacter pylori mediated gastroduodenal diseases. We are also performing the functional analysis of disease-associated polymorphisms to understand the biochemical basis of disease susceptibility.

Research Interest

Genetic and epigenetic alterations of mismatch repair and spindle assembly checkpoint genes in oral cancer are being analysed to understand the molecular basis of genomic instability. The mechanism of spindle assembly checkpoint is being investigated to understand its role in aneuploidy. Systematic search for the single nucleotide polymorphisms in DNA repair genes is being carried out to identify the susceptibility alleles for the development of oral cancer. We are studying the association between cytokine and chemokine genes polymorphisms and Helicobacter pylori mediated gastroduodenal diseases. We are also performing the functional analysis of disease-associated polymorphisms to understand the biochemical basis of disease susceptibility.