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7th Global Summit on Cancer Therapy

Dubai, UAE

 Yunus A Luqmani

Yunus A Luqmani

Kuwait University, Faculty of Pharmacy, Kuwait

Title: Endocrine resistance in breast cancer

Biography

Biography: Yunus A Luqmani

Abstract

Current therapeutic strategies for treating estrogen receptor (ER) positive breast cancer involve either a), reduction of circulating estrogen (in premenopausal women by ovariectomy or chemical ovarian blockade with LHRH analogues such as goserelin or, in postmenopausal women, with aromatase inhibitors such as anastrazole and letrazole and b), application of selective estrogen receptor modulators, such as tamoxifen, raloxifene and fulvestrant for pharmacological receptor blockade. The success of these interventions is limited by the variable but persistent onset of acquired resistance, as well as intrinsic refractiveness due to loss or non-functionality of the target ER. Cellular models of endocrine insensitivity have indicated multiple mechanisms including alternative growth factor mediated signaling independently as well as by constitutive receptor activation by phosphorylation or through epigenetic mechanisms. Drugs targeting single downstream mediators such as tyrosine kinases, mTOR, PI3K, ERK etc. that are effective in vitro have met with limited success in vivo, most likely due to tumour heterogeneity. Loss of cellular adhesion and polarity and increased tumour migratory potential is now attributed to trans-differentiation of epithelial cancer cells into a more motile mesenchymal-like phenotype (EMT) and we have shown this to be linked to ER loss. Reversal of this transition by ectopic expression of key components demonstrates potential to restore epithelial morphology and anti-estrogen sensitivity. The small non-coding microRNAs, recently recognized as critical gene regulators, exhibit differential expression in tamoxifen sensitive vs resistant cell lines, and offer an entirely new more universal mechanism to combat resistance by reversing the aggressive metastatic phenotype by EMT reversal.