25^th World Cancer Conference

Holism is a new concept dealing with Stereotactic Body Radiation Therapy (SBRT) settings. SBRT experts concern with lessening organ toxicity. Use of DVH (dose-volume histogram) solely in SBRT treatment care plan/ protocols might cause grave consequences if other factors ignored. Correlation between specific injury and radiation dose is still uncertain. Sometimes there are discrepancies between studies in defining the injury. There is little known about most of the toxicity mechanisms. Use of biologically equivalent dose model is still controversial. It seems inevitable that SBRT delivery, patient factors (including comorbidities, patient's BMI, gender, habits, age, and ECOG PS score), tumor factors and treatment factors should carefully be examined.