Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer

Back

25th World Cancer Conference

Rome, Italy

Caiyun Zhong

Caiyun Zhong

Nanjing Medical University, China

Title: Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway

Biography

Biography: Caiyun Zhong

Abstract

Cancer stem cells (CSCs) play a crucial role in the process of cancer development. Targeting CSCs may be an effective way for adjuvant therapy to prevent the progression of cancer and prolong life. Phenethyl isothiocyanate (PEITC), the major active component from cruciferous vegetables, exhibits inspiring interventional effects in various human cancers. However, the effects of PEITC on colorectal CSCs and the underlying mechanisms remain unclear. The present study examined the inhibitory effects of PEITC on CSC-like properties in colorectal cancer spheroids. We revealed that PEITC inhibited  the spheroid formation capacity of colorectal cancer cells as well as the expression of colorectal CSCs markers, along with suppression of cell proliferation and induction of apoptosis. Moreover, we illustrated that PEITC down-regulated the activation of Wnt/β-catenin pathway, whereas up-regulation of Wnt/β-catenin diminished the inhibitory effects of PEITC on colorectal CSCs. Taken together, this study suggests that PEITC can be an effective natural compound targeting colorectal CSCs through suppression of Wnt/β-catenin pathway, and thus may be a promising agent for colorectal cancer intervention.