He Li
National Cancer Center/ National Clinical Research Center for Cancer, China
Title: An initial screening strategy based on epidemiological information in the esophageal cancer screening: A prospective evaluation in a community-based cancer screening cohort in rural China
Biography
Biography: He Li
Abstract
Background and Aims:
In China, regional organized esophageal cancer screening programs have been implemented since 2005; however, the implementation of these screening programs is still an overwhelming undertaking, especially for identifying high-risk population. This study aimed to evaluate the risk stratification potential of the current initial assessment strategy used in a mass esophageal squamous cell carcinoma (ESCC) screening program in China. Materials: A total of 43,875 participants without prior cancer history enrolled in a mass ESCC screening program in China from 2007 to 2010 who had initial assessment results were included in this study and were followed until December 31, 2015. Eight potential risk factors for ESCC composed the initial assessment strategy. A comprehensive evaluation of the association of the initial assessment results with ESCC risk was performed by propensity score matching and Cox regression analysis. Results: During a median 5.5 years of follow-up, 272 individuals developed ESCC. Participants with a positive baseline assessment result had a higher risk of ESCC than those with a negative result, with a hazard ratio (HR) of 3.30 (95% confidence interval (CI): 2.51-4.33) after adjustment for sex, age, education level, income level, and body mass index. Additionally, the initial assessment results were significantly associated with the risk of all esophageal cancers (HR=3.30, 95% CI: 2.51-4.33) and upper gastrointestinal cancers (HR=3.42, 95% CI: 2.37-4.95). Conclusions: Positive assessment results in the current initial screening strategy in the mass esophageal cancer screening program in China are associated with an increased incidence of major upper gastrointestinal cancers.