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5th World Congress on Cancer Therapy

Atlanta, USA

Maria Del Carmen Valadez Vega

Instituto de Ciencias de la Salud, Mexico

Title: Cytotoxyc effect of Solanum rastratum dunal (mexican thisle) on cervical cancer cells (Siha)


Biography: Maria Del Carmen Valadez Vega


Some medicinal plants are been used around the word to treat many kinds of diseases such as cancer. In Mexico the people have used plants extracts such as Solanum rastratum, which has shown to be eff ective in improving symptoms of some diseases conditions, there are reports about the use of water extract of this plant for the treatment of cervical cancer. For this reason, in this work the aim was to evaluate the cytotoxyc eff ect of extracts of Solanum rastratum on human cervical cancer Siha. Th e plant was collected, cleaned, separate the sections, and dried in darkness at room temperature. Extracts were prepared from the leaf, stem and fl ower/fruit using methanol, ethyl acetate and hexane. Th e extract cytotoxicity was analyzed on SiHa Cells line employing the MTT technique. Th e results showed higher inhibition eff ect on cell viability with stem ethyl acetate extract with DI50 52 μg/mL, while methanolic extract of leaf and fl ower were which showed lowest inhibitory eff ect. Methanol extract were which showed lowest inhibitory activity, followed by hexane extracts and the better inhibitory activity were showed for ethyl acetate extract in all parts of the plants. We conclude that ethyl acetate extract of the leaf showed the greater cytotoxic eff ect. Th ese results are contrasting with the traditional use of the extract of this plant, since traditionally people employ the aqueous extract of this plant, which would be equivalent to methanolic extract used in this study, which was who presented the lower cytotoxic eff ect of three solvents studied.