5th World Congress on Cancer Therapy
Huazhong Agricultural University, China
Title: SUMOylation: A link to future therapeutics
Biography: Faheem Ahmed Khan
This lecture will focus on SUMOylation, much of a similar process like ubiquitination that catches attention across diff erent research groups as a potential therapeutic target to fi ght various infectious and cancerous diseases. Th is idea take its strength from recent reports which unearth the molecular mechanisms of SUMOylation and its involvement in important diseases distributed across various kingdoms. At the beginning SUMOylation was considered a process aff ected only by viral diseases but subsequent reports enlighten its role in diseases caused by bacteria as well. Th is enhances the SUMOylation canvas and demanded more in-depth study of the process. Th e present discussion will be an attempt to elucidate the regulatory mechanism of genes when the natural SUMOylation pathway is disturbed, the cross-talk among SUMOylation and other post translational modifi cations, the role of miRNAs in controlling the function of transcripts, loading of RNA species into exosomes and the possible SUMOylation related therapeutic targets. Furthermore, SUMOylation and miRNAs as a combined therapeutic target and SUMOylation and anti-cancer drugs will be explored in light of present researches.