5th World Congress on Cancer Therapy
University of Peradeniya, Sri Lanka
Title: Toxicological evaluation of anticancer α- Eleostearic acid rich fat extracted from seeds of bitter melon (Momordicacharantia) using a mouse model
Biography: K.N.K. Ranasinghe
Colorectal cancer is the third most common cancer worldwide. In Sri Lanka burden of colorectal cancer is on the rise. Despite the availability of conventional treatments, a great deal of attention has been attracted by alternative treatment protocols using plant derivatives. Momordica Charantia (Bitter melon/bitter gourd: Family cucurbitaceae) a slender, climbing annual vine is a popular vegetablewith medicinal propertiesfound in tropical countries. A conjugated trienoicfatty acid, namely -Eleostearic Acid (-ESA) is the richest fatty acid in Momordica Charantia seed fat accounting for almost 60% of its total fatty acids. Recent studies have revealed potent anti-cancer properties of -ESA using in vitro and in vivo studies. Cytotoxic eff ects of -ESA on fi brosarcoma cells (HT 1080) was evaluated in our laboratory and revealed apotent cytotoxic action. Furthermore, in a Toxicological evaluation using a mouse model, continuous intake of -ESA rich seed fat did not exhibit any signifi cant adverse eff ect as determined by presence of normal serum levels of enzymes namely SGOT, SGPT and level of serum creatinine. In addition, assessment of haematological parameters and histology of vital organs namely liver, kidney, heart and lung also did not reveal any adverse eff ect by ingestion of - ESA. Th ese studies on safety assessment of - ESA pave the way for conducting further clinical trials in human subjects using - ESA rich seed fat of Momordica Charantia in future.