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25th World Congress on Cancer Science and Therapy

Baltimore, USA

Vanessa Bellat

Weill Cornell Medicine, USA

Title: Nanofibers with unique adaptive and invasive properties for enhanced tumoral retention and anticancer drug delivery

Biography

Biography: Vanessa Bellat

Abstract

A drug delivery system that can cross multiple biological barriers, penetrate solid tumors, and prevent nonspecific body accumulation is in demand for precision treatment. We introduce a smart self-assembling peptide nanofiber that can overcome these challenges by using an approach that combined shape-controlled tumoral uptake, chargeassisted tissue penetration, and enzyme induced retention approach to improve the delivery efficacy of anticancer agents. The nanofiber displays a high aspect ratio to promote tumoral delivery. Multimodal imaging studies reveal the tumor infiltration, invasion, and saturation properties of the nanofibers. In situ activation by tumorassociated proteases structurally transforms the fibers into networks that are more than ten times larger, leading to a weeks-long local retention. Specific examples are given on delivering aldoxorubicin, proceeding as a novel treatment for triple negative breast cancer. The drug-loaded nanofibers release the active metabolites under the acidic tumor microenvironment and display an enhanced antitumor efficacy with minimal host toxicity in immunodeficiency mice bearing tumor explants compared to the free drug and the liposomal formulation.