Saad M Al-Shibli completed his Graduation from College of Medicine, Baghdad University. He got the membership of the Royal College of Surgeons of Ireland in 2004, appointed as an Assistant Professor in Tikrit University, Iraq. Currently, he is a Lecturer in the Anatomy department, College of Medicine, International Islamic University Malaysia and his special interest is Applied Anatomy. He is a part time PhD candidate in Anatomy at the same university.
Introduction: Leptin hormone which is secreted from the adipose tissue and responsible for satiety through its action on leptin receptors was found to have some adverse effects on other tissues. It promotes the tumerogenesis of breast tissue. Aim: Aim of this study is to show the differences between serum leptin levels in normal and cancer group and to compare between serum leptin levels in pre and post-operative patients with breast cancer. Method: In our study, serum leptin levels were measured in the control and study group using ELISA kit. The control group was composed of 40 women with negative mammogram for breast cancer, while the study group were 51 women with intraductal carcinoma of the breast. Pre and postoperative samples were taken from the study group. Results: Significant differences between the control and the study group were observed regarding serum leptin levels; also we found significant correlation between the serum leptin levels and the BMI of the control group. Our study had showed no differences between the pre and post-operative serum leptin levels.
Stephen Joseph P. Garcia, MD is a Medical Oncology fellow-in-training at the Philippine General Hospital. He has numerous experiences in multi-disciplinary cancer therapy. Currently he is involved in several clinical trials employing new therapeutic approach in cancer management.
Introduction: Quality of Life (QoL) is a corner stone in choosing the best approach to treatment among cancer patients. Th e primary aim is to provide excellent tumor response and to maintain the most acceptable quality of life. Th e relationship of QoL to tumor response has not yet been well discussed. Th is study determines the association between the change in the QoL from baseline to one (1) year follow-up and tumor response among patients enrolled in the ASEAN Cost in Oncology (ACTION) study. Methods: Pooled data from the ACTION study was reviewed. Association between demographics, cancer type, and tumor response was analyzed. Results: 412 out of the 742 qualifi ed for analysis. 174 (42.2%) breast cancer cases, 90 (21.8%) colorectal cancer, 51 (12.4%) for other malignant neoplasms and 41 (10%) head and neck were most common. 126 (30.6%) were metastatic. Correlating tumor response and demographic data: female sex, occupation and being household head tended to have better tumor response. Cancer type was also associated with good tumor response (p=.000) as well as metastatic disease (p=.000). Improvement in QoL was signifi cantly associated with tumor response. Complete or partial response was associated with better QOL (p=.000) while progressive disease related to worse situations. Th e general pattern seen above was refl ected in female breast cancer cases, colon and rectal cancer, and other malignant neoplasms. No correlation was seen for head and neck cancer cases. Conclusion: Improvement in QoL was signifi cantly associated with tumor response. Complete or partial response tended to relate with better QOL while progressive disease related to worse situations. Th is trend was similar for breast cancer, colorectal cancer and other malignancies. No association can be drawn for head and neck cancer.